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Dosage

Missed Dose

Oral forms: Take the missed dose as soon as you remember. If it is almost time for the next scheduled dose, then the missed dose can be skipped. Do not use extra medicine to make up for the missed dose. Injectable forms: Since this medicine is usually administered in a clinical/hospital setting, the likelihood of missing a dose is very low. If you miss a scheduled appointment for a dose of this medicine, contact your doctor for further instructions.

Overdose

Oral forms: Seek emergency medical treatment or contact the doctor in case of an overdose. Injectable forms: Since this medicine is usually administered in a clinic/hospital, the likelihood of an overdose is very low. However, emergency medical treatment will be instituted by the doctor if an overdose is suspected.

Interactions

Phenobarbital   (moderate)

Fluorouracil   (severe)

Capecitabine   (severe)

Trimethoprim   (severe)

Ceftriaxone   (severe)

Phenytoin   (moderate)

Methotrexate   (moderate)

Prescribes

Methotrexate rescue

This medicine is used to reduce the toxicity caused due to the administration of methotrexate. It is also used to counteract the effects of an impaired methotrexate elimination or accidental overdosage.

Folic acid antagonist overdose

This medicine is also used to replenish folic acid in the body and reduce the toxicity caused due to the administration of folic acid antagonists such as aminopterin, pyrimethamine, trimethoprim, triamterene, etc. It is also used to counteract the toxic effects caused due to an accidental overdose of these medicines.

Megaloblastic Anemia

This medicine is used to treat megaloblastic anemia, a type of anemia with a lower than the normal number of red blood cells, caused by a deficiency of folic acid due to malnourishment, liver disease, pregnancy, or a reduced ability to absorb folic acid from the diet.

Colorectal Cancer

This medicine is used along with 5-Fluorouracil to prolong survival of the patients suffering from advanced colorectal cancer.

Side Effects

Severe skin rash and hives   (severe)

Swelling of the face, arms, hands, lower legs, or feet   (severe)

Difficulty in breathing   (severe)

Difficulty in swallowing   (severe)

Fainting   (severe)

Fever   (severe)

Convulsions (seizures)   (severe)

Agitation and anxiety   (rare)

Indigestion  

Difficulty in falling asleep  

Peeling and blistering of skin   (severe)

Constipation  

Unusual tiredness or weakness   (rare)

Warnings

Other medicines

Use in elderly

Seizure disorders

Serious allergic reactions

Form of medicine and dosing schedule

Gastrointestinal toxicities

Pregnancy

Breast-feeding

When Not To Use

Allergy

This medicine is not recommended for use in patients with a known allergy to leucovorin/calcium folinate or any other inactive ingredients present in the formulation.

Pernicious anemia

This medicine is not recommended for use in patients suffering from an anemia caused due to the deficiency of vitamin B12.